In one of my favorite science fables, Sydney Brenner supposedly opened a seminar that was meant to be a celebration of structural biology at the storied LMB by saying: ‘I think we can all agree that hydrogen bonds and beta-pleated sheets are boring’. I tell new students and post-docs this legend when we discuss where they want to explore following the Resolution Revolution in cryoEM. We can now determine the atomic structure of just about anything, but we didn’t come here to collect structures. “Seeing is Forgetting the Name of the Thing One Sees” - and each of our projects started with this optimism: structural biology is discovery biology. Our efforts to see the cell’s machinery directly will teach us how living matter works.

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