In one of my favorite science fables, Sydney Brenner supposedly opened a seminar that was meant to be a celebration of structural biology at the storied LMB by saying: ‘I think we can all agree that hydrogen bonds and beta-pleated sheets are boring’. I tell new students and post-docs this legend when we discuss where they want to explore following the Resolution Revolution in cryo-EM. We can now determine the atomic structure of just about anything, but we didn’t come here to collect structures. Each of our diverse projects started with our optimism that structural biology should be discovery biology, that our efforts to see the cell’s machinery directly will teach us how living matter works.

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