Welcome to the Frost lab at the University of California, San Francisco

Work in our lab is connected by a common vision: to see the cell’s macromolecules get together and come to life. We study the molecular machines that are too fragile to purify to homogeneity, too large or too flexible to crystallize, or that depend upon lipids for their form and function. To derive unique insights into cell biology and human disease, we integrate atomic structure determination by cryo-EM with genetics, biochemistry, and diverse imaging techniques. We work within Biochemistry and Biophysics and the Macromolecular Structure Group at UCSF.