Welcome to the Frost lab. We are a part of Altos Labs and work at the San Francisco Bay Area Institute of Science. We are affiliated with the Chan Zuckerberg Biohub, the University of Utah, and the University of California, San Francisco.

Our lab strives to see how molecules get together and come to life. We seek to understand how fuel-driven biological machines work, especially those too fragile to purify, too dynamic or flexible to crystallize, or that depend on lipids for their form and function. We integrate molecular structure determination by electron cryo-microscopy with genetics, biochemistry, and other imaging techniques to derive unique insights into cell health. Our banner art depicts eukaryotic living matter inspired by the efforts of the structural cell biology community.