Frost Lab

Welcome to the Frost lab of the University of California, San Francisco

Our work is connected by a common vision: to see macromolecules get together and come to life. We seek to understand how fuel-driven biological machines work–especailly those that are too fragile to purify to homogeneity, too large or too flexible to crystallize, or that depend on lipids for their form and function. To derive unique insights into cell biology and human disease, we integrate atomic structure determination by cryoEM with genetics, biochemistry, and other imaging techniques. We work within the department of Biochemistry and Biophysics the Macromolecular Structure Group and the Quantitative Biosciences Institute.