Welcome to the Frost lab. In January 2022 we joined Altos Labs and work in the San Francisco Bay Area within the Altos Institute of Science. We also retain collaborative affiliations with the Chan Zuckerberg Biohub, the University of Utah, and the University of California, San Francisco among other institutions.

Our lab strives to see how molecules get together and come to life. We seek to understand how fuel-driven biological machines work, especially those too fragile to purify, too dynamic or flexible to crystallize, or that depend on lipids for their form and function. We integrate molecular structure determination by electron cryo-microscopy with genetics, biochemistry, and other imaging techniques to derive unique insights into cell health. Our banner art depicts eukaryotic living matter inspired by the endeavors of the structural cell biology community. Please visit our Google Scholar Profile for more information.